Melanotan 2 Australia

Melanotan II Australia. Melanotan II binds all five melanocortin receptors, so the reported outcomes span several systems at once. The MC1R work, which is what the compound is best known for, reports melanin synthesis and skin pigmentation. MC4R sits in the central nervous system, which puts lower appetite and food intake on the list along with sexual function endpoints. MC5R work covers sebaceous and exocrine gland activity.

How it does it. Melanotan II is a redesigned copy of α-MSH, one of the body's own signalling hormones. α-MSH works through the melanocortin receptors, a family of five found on different tissues around the body, and the natural hormone is fragile, broken down within minutes. MT-2 takes the short stretch of the molecule the receptors actually read and closes it into a ring with a chemical bridge, locking that section into a fixed shape and making it far harder to break apart. It is not selective. It binds across all five rather than singling one out, which is why receptor pharmacology uses it as the broad reference agonist.

What the safety literature reports. This belongs alongside the results rather than buried after them. Reported effects include nausea and flushing, and there are documented reports of changes to existing moles and of melanoma in people using unregulated melanotan. That is why the pigmentation research consistently emphasises monitoring pigmented lesions.

The vial. Independently HPLC-tested above 99% purity by Janoshik, with the certificate of analysis published on this page and in the lab-reports library, carrying the measured number and a verifiable Janoshik key. Supplied in a 10 mg freeze-dried vial, dispatched from Australia, AUD pricing. Supplied strictly for in-vitro and laboratory research use only. Not for human or animal consumption, not a therapeutic good, not TGA-approved.

Melanotan II (CAS 121062-08-6; molecular formula C50H69N15O9, average molecular weight ≈ 1024 g/mol) is a cyclic heptapeptide built on the conserved α-MSH His-Phe-Arg-Trp message core. Its structure is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂: the ring is closed by a lactam bridge between the Asp side-chain and the Lys side-chain, and the norleucine (Nle) and D-phenylalanine substitutions rigidify the pharmacophore — the structural basis for its receptor affinity and metabolic stability relative to native α-MSH.

In receptor and pathway research, MT-2 is studied as a non-selective (pan-)melanocortin receptor agonist, with reported agonist activity across the MC1R, MC3R, MC4R and MC5R receptor subtypes. The cyclic lactam α-melanotropin scaffold was designed and reported by Al-Obeidi and colleagues (Journal of Medicinal Chemistry, 1989); the receptor-subtype selectivity of D-Phe⁷- and D-Nal⁷-substituted MSH analogues, including MT-2, was characterised across cloned human melanocortin receptors by Schiöth and colleagues (Peptides, 1997).

The His-Phe-Arg-Trp message sequence shared with α-MSH is the pharmacophore that determines melanocortin-receptor recognition, and the cyclic lactam constraint together with the Nle⁴ and D-Phe⁷ substitutions was introduced specifically to lock that pharmacophore into a rigid, protease-resistant conformation. That structure–activity work on melanotropin templates — including the stereochemical analysis of Haskell-Luevano and colleagues (Journal of Medicinal Chemistry, 1997) — is the reason MT-2 is used as a high-affinity reference agonist in melanocortin-receptor binding assays.

MT-2 is a standard reference ligand in melanocortin-receptor pharmacology — used to probe receptor binding, subtype selectivity, and downstream signalling in receptor-research models. Its value in research is as a rigidified, metabolically stable α-MSH analogue for receptor-pathway work.

The information provided here is a research-reference summary only. Elite AU Peptides makes no medical, therapeutic, cosmetic, tanning, pigmentation, or human-use claim about this product, and publishes no before-and-after material. Melanotan II is not TGA-approved, is not a therapeutic good, and is supplied strictly for in-vitro and laboratory research use only. Researchers should consult the primary peer-reviewed literature for receptor-binding affinities and protocol-specific reference values.

Reconstitute the lyophilised Melanotan II vial with bacteriostatic water for laboratory handling. The peptide is water-soluble; add the diluent slowly down the vial wall and swirl gently rather than shaking. A 10 mg vial reconstituted in 2 mL of bacteriostatic water yields a 5 mg/mL working stock — adjust to your protocol’s target concentration.

Store the lyophilised powder at −20°C, desiccated and protected from light; once reconstituted, store refrigerated at 2–8°C and use within the documented research window, or aliquot and freeze to avoid repeated freeze-thaw cycles. Tamper-evident packaging; the batch label is the canonical reference for the certificate of analysis published in the lab-reports library.

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30-day returns on unused product in original packaging, with prior approval.