Melanotan 2 Australia

Melanotan II Australia. Melanotan II (MT-2) is a synthetic cyclic heptapeptide studied in laboratory research as a melanocortin-receptor agonist — a lactam-bridged analogue of α-melanocyte-stimulating hormone (α-MSH). The Elite AU Peptides Melanotan II is independently HPLC-tested above 99% purity by Janoshik; the certificate of analysis is published on this page and in the lab-reports library, with the measured number and an independently verifiable Janoshik key.

Stocked and dispatched AU-domestic in a 10 mg lyophilised vial, AUD pricing. Every batch is held until the independent HPLC report comes back within our acceptance threshold; nothing is listed without a certificate on file. Supplied strictly for in-vitro and laboratory research use only — not for human or animal consumption, not a therapeutic good, not TGA-approved.

Melanotan II (CAS 121062-08-6; molecular formula C50H69N15O9, average molecular weight ≈ 1024 g/mol) is a cyclic heptapeptide built on the conserved α-MSH His-Phe-Arg-Trp message core. Its structure is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂: the ring is closed by a lactam bridge between the Asp side-chain and the Lys side-chain, and the norleucine (Nle) and D-phenylalanine substitutions rigidify the pharmacophore — the structural basis for its receptor affinity and metabolic stability relative to native α-MSH.

In receptor and pathway research, MT-2 is studied as a non-selective (pan-)melanocortin receptor agonist, with reported agonist activity across the MC1R, MC3R, MC4R and MC5R receptor subtypes. The cyclic lactam α-melanotropin scaffold was designed and reported by Al-Obeidi and colleagues (Journal of Medicinal Chemistry, 1989); the receptor-subtype selectivity of D-Phe⁷- and D-Nal⁷-substituted MSH analogues, including MT-2, was characterised across cloned human melanocortin receptors by Schiöth and colleagues (Peptides, 1997).

The His-Phe-Arg-Trp message sequence shared with α-MSH is the pharmacophore that determines melanocortin-receptor recognition, and the cyclic lactam constraint together with the Nle⁴ and D-Phe⁷ substitutions was introduced specifically to lock that pharmacophore into a rigid, protease-resistant conformation. That structure–activity work on melanotropin templates — including the stereochemical analysis of Haskell-Luevano and colleagues (Journal of Medicinal Chemistry, 1997) — is the reason MT-2 is used as a high-affinity reference agonist in melanocortin-receptor binding assays.

MT-2 is a standard reference ligand in melanocortin-receptor pharmacology — used to probe receptor binding, subtype selectivity, and downstream signalling in receptor-research models. Its value in research is as a rigidified, metabolically stable α-MSH analogue for receptor-pathway work.

The information provided here is a research-reference summary only. Elite AU Peptides makes no medical, therapeutic, cosmetic, tanning, pigmentation, or human-use claim about this product, and publishes no before-and-after material. Melanotan II is not TGA-approved, is not a therapeutic good, and is supplied strictly for in-vitro and laboratory research use only. Researchers should consult the primary peer-reviewed literature for receptor-binding affinities and protocol-specific reference values.

Reconstitute the lyophilised Melanotan II vial with bacteriostatic water for laboratory handling. The peptide is water-soluble; add the diluent slowly down the vial wall and swirl gently rather than shaking. A 10 mg vial reconstituted in 2 mL of bacteriostatic water yields a 5 mg/mL working stock — adjust to your protocol’s target concentration.

Store the lyophilised powder at −20°C, desiccated and protected from light; once reconstituted, store refrigerated at 2–8°C and use within the documented research window, or aliquot and freeze to avoid repeated freeze-thaw cycles. Tamper-evident packaging; the batch label is the canonical reference for the certificate of analysis published in the lab-reports library.

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Australia only. Free shipping over $100. Orders placed before 12pm AEST are dispatched the same business day from Australia.

30-day returns on unused product in original packaging, with prior approval.