MOTS-C Australia

MOTS-c Australia. MOTS-c is the metabolic and exercise peptide. The research reports better insulin sensitivity and glucose handling, resistance to weight gain in animals fed high fat diets, and higher mitochondrial output, meaning cells producing more energy. Levels rise naturally with physical activity, so a large part of the work looks at endurance and exercise capacity, and at whether it offsets the metabolic decline that comes with age.

How it does it. MOTS-c has an unusual origin. It is written into the DNA of the mitochondria, the compartments that generate a cell's energy, rather than into the DNA of the nucleus. It works by switching on AMPK, the enzyme cells use as a fuel gauge. When AMPK is activated the cell shifts from storing energy to burning it.

The vial. Independently HPLC-tested by Janoshik, with the certificate of analysis published on this page and in the lab-reports library, carrying the measured number and a verifiable Janoshik key. Supplied in 10 mg, 20 mg and 40 mg freeze-dried vials, dispatched from Australia, AUD pricing. Supplied strictly for in-vitro and laboratory research use only. Not for human or animal consumption, not a therapeutic good, not TGA-approved.

MOTS-c (CAS 1627580-64-6; molecular formula C101H152N28O22S2, average molecular weight ≈ 2175 g/mol; sequence MRWQEMGYIFYPRKLR) is a 16-residue mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region — its name stands for Mitochondrial Open reading frame of the Twelve S rRNA-c. It is referenced across mitochondrial-stress, metabolic-research and cellular-senescence literature.

MOTS-c was identified and characterised by Lee and colleagues (Cell Metabolism, 2015), who described the peptide, its mitochondrial origin, and its role in the folate–methionine (AICAR) pathway leading to AMP-activated protein kinase (AMPK) activation and metabolic-homeostasis research readouts.

Later work by Reynolds and colleagues (Nature Communications, 2021) reported MOTS-c as an exercise-responsive, mitochondrially-encoded regulator that translocates to the nucleus to influence stress-adaptive and metabolic gene programmes in research models. These two studies anchor MOTS-c as a reference peptide for AMPK-pathway and mitochondrial-stress research.

Within the longevity strand of the catalogue MOTS-c is frequently referenced alongside NAD+ (a cofactor for sirtuin-pathway research) and SS-31 (a mitochondrial-membrane-targeting tetrapeptide); researchers compare the mitochondrial-derived-peptide class (MOTS-c, humanin, the SHLPs) with these other mitochondrial-research tools.

The information provided here is a research-reference summary only. Elite AU Peptides makes no medical, therapeutic, anti-ageing, longevity, or human-use claim about this product. MOTS-c is not TGA-approved, is not a therapeutic good, and is supplied strictly for in-vitro and laboratory research use only. Researchers should consult the primary peer-reviewed literature for pathway data and protocol-specific reference values.

Reconstitute the lyophilised MOTS-c vial with bacteriostatic water for laboratory handling. Add the diluent slowly down the vial wall and swirl gently rather than shaking. The required volume depends on the protocol’s downstream assay requirements — a 10 mg vial reconstituted in 2 mL of bacteriostatic water yields a 5 mg/mL working stock.

Store the lyophilised powder at −20°C, desiccated and protected from light; once reconstituted, store refrigerated at 2–8°C and use within the documented research window, or aliquot and freeze to avoid repeated freeze-thaw cycles. Tamper-evident packaging; the batch label is the canonical reference for the certificate of analysis published in the lab-reports library.

Shop bacteriostatic water

Australia only. Free shipping over $100. Orders placed before 12pm AEST are dispatched the same business day from Australia.

30-day returns on unused product in original packaging, with prior approval.