Epithalon (also written Epitalon) is a synthetic tetrapeptide — Ala-Glu-Asp-Gly (AEDG) — a pineal-peptide bioregulator referenced across telomere-biology and cellular-ageing research literature. Elite AU Peptides supplies it strictly for in-vitro and laboratory research use only — not for human or animal consumption, not a therapeutic good, and not TGA-approved. No anti-ageing or longevity-outcome claim is made about it.

Is Epithalon the same as Epitalon?

Yes — “Epithalon” and “Epitalon” are two spellings of the same Ala-Glu-Asp-Gly (AEDG) tetrapeptide. Both refer to the identical compound; the product page and certificate use the same molecule regardless of spelling.

What research is Epithalon associated with?

In cellular-ageing research, Epithalon is studied primarily for reported effects on telomerase (hTERT) expression and telomere length in cultured human somatic cells — first reported by Khavinson and colleagues (Bulletin of Experimental Biology and Medicine, 2003). In-vivo ageing-biomarker work was reported by Anisimov and colleagues (Biogerontology, 2003). A recent comprehensive review (Araj and colleagues, International Journal of Molecular Sciences, 2025) surveys twenty-five years of work and notes the precise molecular mechanism remains an open research question.

How is research-grade Epithalon tested?

Every batch is independently HPLC-tested by Janoshik Analytical before it is listed. The measured purity is published on the product page and in the lab-reports library — a real batch number, the measured percentage, and an independently verifiable Janoshik report; nothing is listed without a certificate on file.

How is Epithalon reconstituted and stored for research use?

As a small, highly polar tetrapeptide it is freely water-soluble. Reconstitute with bacteriostatic water — for example, a 10mg vial in 2mL yields a 5mg/mL working stock. Store the lyophilised powder at −20°C protected from light; once reconstituted, refrigerate at 2–8°C and use within the documented research window.

How is Epithalon shipped in Australia?

Stock is held and dispatched AU-domestic — no inbound customs handling. Free shipping over $100; orders placed before 12pm AEST are dispatched the same business day. Supplied strictly for laboratory research use only.

[ Longevity research ]

Epithalon in Australia: a telomere-biology research guide

What Epithalon (Epitalon) is — the Ala-Glu-Asp-Gly pineal tetrapeptide referenced across telomere-biology and cellular-ageing research — where it sits in the literature, and how research-grade material is HPLC-verified. A laboratory research reference for Australian researchers.

7 min read · Updated 22 July 2026

Epithalon (AEDG) research peptide vial — 10mg, independently HPLC-tested, COA on file

[ Research use only · Not for human consumption ]

Epithalon in Australia. Epithalon (also written Epitalon) is a synthetic tetrapeptide — Ala-Glu-Asp-Gly (AEDG) — a pineal-peptide bioregulator referenced across telomere-biology and cellular-ageing research literature. This guide is a research-reference summary for Australian researchers. It makes no anti-ageing, longevity-outcome, or human-use claim.

What Epithalon is

Epithalon is a short synthetic “peptide bioregulator” modelled on the pineal polypeptide preparation epithalamin, developed within the peptide-bioregulator research programme associated with Khavinson and colleagues. The two spellings — “Epithalon” and “Epitalon” — refer to the same Ala-Glu-Asp-Gly (AEDG) tetrapeptide; the product page and certificate use the identical molecule regardless of spelling.

Telomere-biology and cellular-ageing research

In cellular-ageing research, Epithalon is studied primarily for reported effects on telomerase (hTERT) expression and telomere length in cultured human somatic cells — the finding first reported by Khavinson and colleagues (Bulletin of Experimental Biology and Medicine, 2003), who described induction of telomerase activity and telomere elongation in human fibroblasts. In-vivo ageing-biomarker work by Anisimov and colleagues (Biogerontology, 2003) examined the peptide against markers of ageing in rodent models. A recent comprehensive peer-reviewed review (Araj and colleagues, International Journal of Molecular Sciences, 2025) surveys twenty-five years of work and notes the precise molecular mechanism remains an open research question.

A model tetrapeptide, not a single-receptor ligand

Because it carries no receptor of its own, Epithalon is used less as a selective ligand and more as a small, well-defined model tetrapeptide for probing telomere-maintenance and gene-regulation questions in cell-culture research. The Ala-Glu-Asp-Gly motif recurs across a body of work examining peptide effects on gene expression in cultured cells, which is what makes it a practical reference compound in that strand of the literature.

Epithalon in the longevity strand

Within the catalogue, Epithalon sits in the longevity & anti-ageing research category alongside NAD+ (a cellular cofactor referenced in sirtuin-pathway research) and MOTS-c (a mitochondrial-derived peptide). Researchers working across the cellular-ageing literature frequently reference these compounds together; the MOTS-c research guide covers the mitochondrial side.

Identity, purity and handling

Every batch of Epithalon is independently HPLC-tested by Janoshik before it is listed, with the certificate published on the product page and in the lab-reports library. As a small, highly polar tetrapeptide it is freely water-soluble; reconstitute with bacteriostatic water (a 10mg vial in 2mL yields a 5mg/mL working stock), store the powder at −20°C and, once reconstituted, at 2–8°C within the documented research window. Epithalon is not TGA-approved and is not a therapeutic good — supplied strictly for in-vitro and laboratory research use only.

[ Frequently asked ]

Longevity research — questions researchers ask.

What is Epithalon?: Epithalon (also written Epitalon) is a synthetic tetrapeptide — Ala-Glu-Asp-Gly (AEDG) — a pineal-peptide bioregulator referenced across telomere-biology and cellular-ageing research literature. Elite AU Peptides supplies it strictly for in-vitro and laboratory research use only — not for human or animal consumption, not a therapeutic good, and not TGA-approved. No anti-ageing or longevity-outcome claim is made about it.
Is Epithalon the same as Epitalon?: Yes — “Epithalon” and “Epitalon” are two spellings of the same Ala-Glu-Asp-Gly (AEDG) tetrapeptide. Both refer to the identical compound; the product page and certificate use the same molecule regardless of spelling.
What research is Epithalon associated with?: In cellular-ageing research, Epithalon is studied primarily for reported effects on telomerase (hTERT) expression and telomere length in cultured human somatic cells — first reported by Khavinson and colleagues (Bulletin of Experimental Biology and Medicine, 2003). In-vivo ageing-biomarker work was reported by Anisimov and colleagues (Biogerontology, 2003). A recent comprehensive review (Araj and colleagues, International Journal of Molecular Sciences, 2025) surveys twenty-five years of work and notes the precise molecular mechanism remains an open research question.
Does Epithalon act on a specific receptor?: It carries no receptor of its own — Epithalon is used less as a selective ligand and more as a small, well-defined model tetrapeptide for probing telomere-maintenance and gene-regulation questions in cell-culture research. The Ala-Glu-Asp-Gly motif recurs across a body of peptide-bioregulator work.
How is research-grade Epithalon tested?: Every batch is independently HPLC-tested by Janoshik Analytical before it is listed. The measured purity is published on the product page and in the lab-reports library — a real batch number, the measured percentage, and an independently verifiable Janoshik report; nothing is listed without a certificate on file.
How is Epithalon reconstituted and stored for research use?: As a small, highly polar tetrapeptide it is freely water-soluble. Reconstitute with bacteriostatic water — for example, a 10mg vial in 2mL yields a 5mg/mL working stock. Store the lyophilised powder at −20°C protected from light; once reconstituted, refrigerate at 2–8°C and use within the documented research window.
How is Epithalon shipped in Australia?: Stock is held and dispatched AU-domestic — no inbound customs handling. Free shipping over $100; orders placed before 12pm AEST are dispatched the same business day. Supplied strictly for laboratory research use only.

[ Referenced in this guide ]

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Elite AU Peptides supplies research peptides and related compounds for laboratory and in-vitro research use only. Products are not therapeutic goods, are not TGA-approved, and are not for human or animal consumption. Nothing on this site constitutes medical advice or a therapeutic claim. Purchasers must be 18 years or older and are responsible for complying with all applicable laws in their jurisdiction.