[ Receptors & pathways ]
Incretin
Gut hormones (GLP-1, GIP) whose receptors GLP-class research peptides are studied against.
The incretin system refers to gut hormones — principally GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) — that act on their own G-protein-coupled receptors as part of glucose-dependent insulin signalling and energy-homeostasis physiology.
The GLP-1 and GIP receptors, together with the related glucagon receptor, are the targets that GLP-class research peptides such as retatrutide are studied against. Compounds in this space differ mainly in how many of these receptors they engage.
[ Where this term is used ]
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